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December 8, 2025Blood

Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia

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Authors

LHLubna HamdanYEYasmin El-GammalASAmy Shova

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Overview

Longitudinal study reveals biomarkers may better assess ineffective erythropoiesis in anemia among transfusion-dependent thalassemia patients, suggesting tailored transfusion strategies.

Key Points

  • Observed a significant negative correlation between hemoglobin and ineffective erythropoiesis biomarker levels.
  • Data from 42 longitudinal samples across five patients demonstrated strong inter-patient variability in erythroferrone levels.
  • Longitudinal study assessed hemoglobin, erythroferrone, and growth differentiation factor-15 using clinical records and ELISA.
  • Findings suggest key biomarkers enable personalized transfusion strategies in managing iron overload in thalassemia patients.

Cite This Study

Hamdan et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dad6https://doi.org/10.1182/blood-2025-4684
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world comparative effects of curative and disease-modifying therapies on ineffective erythropoiesis in beta-thalassemia2025
  2. 2Role of Erythroferrone and Hepcidin in Iron Overload and Correlation with Hepatic Fibrosis Complications in Beta-thalassemia Major Pediatric Patients2025 · 1 citations
  3. 3R2* MRI in evaluation of hepatic iron overload and its correlation with serum ferritin in transfusion-dependent beta-thalassemia2025
  4. 4Genetic biomarkers and crucial cell subsets of iron metabolism in Beta-Thalassemia: insights from bioinformatics and experimental validation2025
  5. 5Biomarkers of ineffective erythropoiesis in patients with sickle cell anemia, at baseline and while treated with hydroxyurea, in comparison to patients with other iron-loading red cell disorders2025