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December 8, 2025Blood

Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease

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Authors

AHAnoosha HabibiInsermYZYosr ZaoualiInsermNHNicolas HebertInserm

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Implication

Analysis reveals iron deficiency reduces fetal hemoglobin levels in sickle cell disease patients on hydroxyurea, suggesting potential treatment adjustments needed.

Key Points

  • Iron deficiency significantly limits fetal hemoglobin production, impacting the effectiveness of hydroxyurea in treating sickle cell disease.
  • Among patients on hydroxyurea, those with iron deficiency had a higher occurrence of vaso-occlusive crises, showing a direct negative effect of iron status.
  • Assessment of reticulocytes and transferrin saturation is crucial, highlighting the need for screening iron levels to optimize hydroxyurea therapy.
  • Iron supplementation might be essential for patients with sickle cell disease on hydroxyurea, as their treatment response can be diminished by iron deficiency.

Cite This Study

Habibi et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d70ahttps://doi.org/10.1182/blood-2025-299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic intensification of red cell exchange with hydroxyurea decreased the transfusion burden in patients with sickle cell disease: A single-center retrospective cohort study2025 · 1 citations
  2. 2The Indian experience with hydroxyurea in sickle cell disease: A 25-year systematic review2025 · 1 citations
  3. 3Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  4. 4Evaluation of the Clinical and Haematological Response to Hydroxyurea Treatment in Patients with Sickle Cell Disease Attending the Haematology Clinic at Jitimai District Hospital2025
  5. 5Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025