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December 8, 2025Blood

Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea

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Authors

ATAnifat TijaniCincinnati Children's Hospital Medical CenterRWRussell E. WareCincinnati Children's Hospital Medical CenterPMPunam MalikCincinnati Children's Hospital Medical Center

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Implication

Randomized trial reduced vaso-occlusive pain in sickle cell disease, suggesting antioxidants may alleviate hemoglobin C damage.

Key Points

  • Hemoglobin C-related oxidative stress reduces red blood cell deformability, impacting blood flow.
  • A significant reduction in reactive oxygen species was observed in murine models treated with antioxidants.
  • Assessment utilized ektacytometry to measure sickling kinetics and hemoglobin denaturation.
  • These findings underline the importance of managing oxidative stress in hemoglobin SC disease.

Cite This Study

Tijani et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e183https://doi.org/10.1182/blood-2025-7
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Also Consider

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  1. 1PO85 | Acute retinal ischemia in hemoglobin SC disease: a case report and review of the literature2025
  2. 2The Protective Effect of Fetal Hemoglobin on Retinal Damage in Sickle Cell Disease Patients: A Correlation With Optical Coherence Tomography, Hematologic Parameters, and Hydroxyurea Treatment2025 · 3 citations
  3. 3Mean corpuscular hemoglobin modulates HbF distribution and sub-phenotypes of sickle cell disease2025
  4. 4Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  5. 5Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease2025