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October 1, 2025CellsOpen Access

Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis

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Authors

TZTing ZhangAMAtsuko MatsunagaXLXiaocui Lu

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Overview

Analysis identifies immune suppressive macrophages in leukemia models, suggesting targeting may enhance survival.

Key Points

  • Circulating macrophages promote immune suppression in FGFR1-driven leukemia models, leading to poor outcomes.
  • Increased levels of macrophages from myeloid derived suppressor cells are observed in leukemic mouse models.
  • scRNA-Seq reveals continuous transcriptional reprogramming of these macrophages during leukemia progression.
  • Targeting these leukemia-induced macrophages improves immune surveillance and enhances survival in mice.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc4996adhttps://doi.org/10.3390/cells14191533
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