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December 8, 2025BloodOpen Access

Targeting hedgehog signaling/KL4-dependent M2 macrophage polarization for treatment of chronic graft-versus-host diseases and tissue fibrosis

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Authors

YYYiping Yang

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Overview

Observational analysis revealed hedgehog signaling influences macrophage polarization in cGVHD, suggesting new treatment strategies.

Key Points

  • Therapeutic intervention using hedgehog signaling significantly improved outcomes in chronic graft-versus-host disease.
  • Transgenic mice exhibiting enhanced regulations of macrophage showed reduced tissue fibrosis and prolonged survival.
  • Analysis focused on the macrophage response and therapeutic efficacy of targeting hedgehog signaling in mice models.
  • Study highlights critical roles of macrophage polarization in cGVHD, calling for further investigation into this therapeutic pathway.

Cite This Study

Yiping Yang (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d92chttps://doi.org/10.1182/blood-2025-583
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