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December 8, 2025Blood

CD8+hla-DR+CD27+ t cells define a population of naturally occurring regulatory precursors in humans

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Authors

HGHuidong GuoBWBixia Wang

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Overview

Observational analysis shows CD8+ regulatory T cells expanded FOXP3+ Tregs in allo-HSCT recipients, indicating strong immunosuppressive potential.

Key Points

  • CD8+ regulatory T cells expanded FOXP3+ Tregs and suppressed graft-versus-host disease.
  • Utilizing single-cell RNA sequencing, this study identified specific immune cell populations in transplant recipients.
  • Co-culture assays demonstrated the functional capacity of CD8+ regulatory T cells to enhance regulatory T cell responses.
  • Findings suggest a critical role for CD8+ regulatory T cells in establishing immune homeostasis post-allogeneic stem cell transplantation.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dab7https://doi.org/10.1182/blood-2025-4080
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