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December 8, 2025BloodOpen Access

Liver-targeted delivery of bioengineered induced tregs via nanoparticles prevents and treats acute gvhd

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Authors

HHHyesun HyunMSMathew SebastianAWAndrew Z. Wang

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Overview

Induced regulatory T cell therapy shows improved outcomes in acute graft-versus-host disease by targeting the liver with nanoparticles, highlighting enhanced immune regulation.

Key Points

  • Liver-targeted DBCO-iTregs significantly improved survival and reduced acute graft-vers-host disease severity after bone marrow transplant.
  • Therapeutic effects were observed in mice with reduced clinical GvHD scores and lower serum AST/ALT levels.
  • This approach employs bioorthogonal click chemistry and lipid-coated nanoparticles for effective cellular targeting.
  • Findings suggest potential for combining immune modulation in transplantation while preserving graft-versus-leukemia activity.

Cite This Study

Hyun et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6cchttps://doi.org/10.1182/blood-2025-5861
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Nanoparticle-based Localised Immunomodulation to Reduce Graft-versus-host Disease in Murine Model of Bone Marrow Transplantation: A Systematic Review2025
  2. 2Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks2025 · 1 citations
  3. 3CD8 regulatory T cell therapy in transplantation: a new path to clinical success?2026
  4. 4Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells2025 · 6 citations
  5. 5Ornithine decarboxylase deficiency in donor T cells preserves strong GVL activity while attenuating acute and preventing steroid-resistant gut GVHD in a recipient tissue PD-L1-dependent manner2025