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December 8, 2025BloodOpen Access

Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.

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Authors

CLChristopher T. LetsonTGThomas GirardSOStephen T. Oh

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Overview

Observational analysis revealed TNFα drives platelet hyperreactivity via hematopoietic stem cells and megakaryocyte progenitors.

Key Points

  • Hyperreactive platelets are driven by TNFα-induced changes in hematopoietic stem cells.
  • Single cell RNA sequencing revealed megakaryocyte-specific signaling pathways impacted by TNFα.
  • Chronic TNFα treatment skewed hematopoiesis, leading to expanded megakaryocyte progenitors.
  • Findings suggest a novel mechanism of THFα in influencing platelet dysfunction and developing prothrombotic states.

Cite This Study

Letson et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8f0https://doi.org/10.1182/blood-2025-1250
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophage CD38 overexpression drives primary platelet engraftment failure via paracrine suppression following allogeneic hematopoietic stem cell transplantation2025
  2. 2Tet2 clonal hematopoiesis enhances thrombotic pathologies, increases platelet reactivity, and alters megakaryote function in the context of aging2025
  3. 3A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging2025 · 2 citations
  4. 4Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms2025
  5. 5Tet2 age-associated somatic mutations impair megakaryopoiesis, drive platelet reactivity and enhance thrombosis 31052025