Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Tet2 clonal hematopoiesis enhances thrombotic pathologies, increases platelet reactivity, and alters megakaryote function in the context of aging

View Full Paper
Ask AI
Bookmark
Share

Authors

ECEstelle CarminitaIBIsabelle C. BeckerJIJoseph E. Italiano

Discussion

Loading...

Member takes

Overview

Observational analysis shows increased platelet reactivity in aged individuals with clonal hematopoiesis, indicating higher thrombotic risks.

Key Points

  • Age-related clonal hematopoiesis alters platelet reactivity and enhances thrombotic pathologies among older adults.
  • Tet2 loss-of-function mutations show strong associations with cardiovascular diseases and platelet dysfunction.
  • Proteomic analysis reveals key alterations in mitochondrial metabolism linked to Tet2-deficient platelets.
  • Findings suggest a critical role for Tet2 mutations in thrombosis, emphasizing potential targets for therapeutic interventions.

Cite This Study

Carminita et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e252https://doi.org/10.1182/blood-2025-4946
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tet2 age-associated somatic mutations impair megakaryopoiesis, drive platelet reactivity and enhance thrombosis 31052025
  2. 2Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease2025 · 24 citations
  3. 3Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis2025
  4. 4Perturbation of iNKT differentiation during clonal hematopoiesis from rewiring of inflammation and lipid presentation2025
  5. 5Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.2025