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December 8, 2025BloodOpen Access

Macrophage CD38 overexpression drives primary platelet engraftment failure via paracrine suppression following allogeneic hematopoietic stem cell transplantation

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Authors

HHHua HeQSQin Shi

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Overview

Observational analysis shows macrophage CD38 overexpression links to platelet recovery failure, suggesting CD38 inhibition may aid treatment.

Key Points

  • Platelet recovery failure correlates with macrophage CD38 overexpression, highlighting its role in hemato-poietic complications.
  • Patients with thrombocytopenia showed altered cytokine profiles, with increased pro-inflammatory cytokines and decreased anti-inflammatory markers.
  • Assessment using macrophage CD38-knockout mice revealed enhanced megakaryocyte differentiation and platelet recovery compared to controls.
  • Interventions targeting CD38, like αCD38 therapy, may provide substantial improvements for thrombocytopenia post-transplantation.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d880https://doi.org/10.1182/blood-2025-4202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor necrosis factor-alpha (TNFα) drives pathologic platelet hyperreactivity through signaling on hematopoietic stem/progenitor cells and expansion of canonical megakaryocytic progenitors.2025
  2. 2High-dimensional profiling reveals predominant depletion of NK cell effector phenotypes in relapsed/refractory multiple myeloma patients treated with anti-CD38 therapy2025
  3. 3Single-cell transcriptomic studies reveal altered heterogeneity in CD41 enriched megakaryocytes after targeted therapy in myeloproliferative neoplasm2025
  4. 4Metabolic reprogramming of megakaryocyte subpopulations in ITP: Implications for TSPO in predicting response to TPO-RA2025 · 1 citations
  5. 5Targeting macrophages prevents alloantibody-mediated platelet clearance in a murine model of transfusion refractoriness2025