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September 25, 2025Aging CellOpen Access

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging

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Authors

BMBryce MansoPMPaloma MedinaSSStephanie Smith‐Berdan

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Overview

This study reveals that aging promotes distinct megakaryocyte progenitors, enhancing thrombopoiesis and platelet generation.

Key Points

  • Aged hematopoietic stem cells generate more megakaryocyte progenitors, enhancing thrombopoiesis.
  • Single-cell RNA sequencing identified unique populations of megakaryocyte progenitors in young and aged mice.
  • Aged megakaryocyte progenitors exhibit enhanced survival and platelet generation capacity compared to their younger counterparts.
  • These findings indicate significant functional heterogeneity among megakaryocyte progenitors influenced by aging.

Cite This Study

Manso et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd5ddc445aa9033afcc4https://doi.org/10.1111/acel.70221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a development-restricted, megakaryocyte-primed population of hematopoietic progenitor cells during fetal and early postnatal development2025
  2. 2Immunomodulatory role of megakaryocytes in the hematopoietic niche of myeloproliferative neoplasms2026 · 1 citations
  3. 3Identification of two distinct human hematopoietic stem cell subsets and their age-dependent dynamics by single-cell multi-omics2025 · 1 citations
  4. 4Tet2 clonal hematopoiesis enhances thrombotic pathologies, increases platelet reactivity, and alters megakaryote function in the context of aging2025
  5. 5Tet2 age-associated somatic mutations impair megakaryopoiesis, drive platelet reactivity and enhance thrombosis 31052025