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December 8, 2025BloodOpen Access

Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms

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Authors

TPTyler M. ParsonsAKAishwarya KrishnanMCMaggie Cox

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Overview

Analysis shows cytokine-mediated signals drive independent leukemic clones in JAK2V617F myeloproliferative neoplasms, highlighting therapeutic potential with ustekinumab.

Key Points

  • Leukemic clones can arise from non-JAK2-mutant cells, indicating complex evolution in cancer.
  • Single-cell DNA sequencing revealed cytokine profiles linked to TET2 mutations in hematopoietic progenitor cells.
  • Exposure to Jak2-mutant environments increases proliferation and differentiation of TET2-mutant clones.
  • Targeting IL-12 and TNFα may offer new therapeutic strategies to manage myeloproliferative neoplasms.

Cite This Study

Parsons et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5a1https://doi.org/10.1182/blood-2025-5538
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