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December 8, 2025BloodOpen Access

Characterising the leukaemic microenvironment in a mouse model of infant AML with prenatal KMT2A-MLLT3 expression

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Authors

MBMeryam BeniazzaCHChristina HalseyJSJuerg Schwaller

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Overview

Analysis shows alterations in stromal cells and extracellular matrix in infant AML, suggesting limited efficacy of therapies.

Key Points

  • Leukaemic microenvironment exhibits significant depletion of supportive stromal cells and altered extracellular matrix expression.
  • Single-cell RNA-sequencing reveals complex interactions and communication pathways among bone marrow cells.
  • Cell-to-cell communication strategies highlight key roles for TGF-β1 in promoting an immunosuppressive environment in AML.
  • Chemo therapy may face challenges due to the unique vulnerabilities of infants with KMT2A-MLLT3-driven leukaemia.

Cite This Study

Beniazza et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d809https://doi.org/10.1182/blood-2025-3178
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  4. 4Pre-malignant extracellular matrix drives leukemia transformation through reprogramming of pre-leukemic stem cells2025
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