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December 8, 2025Blood

AML blasts and monocytic myeloid-derived suppressor cells (M-MDSC) inhibit human mucosal-associated invariant t (MAIT) cells activation.

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Authors

CCCharlotte CalvoEDElise Diaz

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Overview

Experimental analysis reveals AML blasts and MDSCs inhibit T-cell activation in humans, suggesting challenges for immune responses.

Key Points

  • MAIT cells exhibit potent cytotoxic functions, but AML blasts significantly inhibit their activation and proliferation.
  • Granzyme B is a crucial marker reflecting the cytotoxic activity of MAIT cells during immune responses against AML.
  • Transcriptomic analyses show T-cell exhaustion markers in MAIT cells when co-cultured with AML blasts and MDSCs.
  • Understanding these interactions may provide insights into enhancing anti-leukemic immunity and managing infections post-HSCT.

Cite This Study

Calvo et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e2https://doi.org/10.1182/blood-2025-5860
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-neutrophil axis2025 · 5 citations
  2. 2MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment2025 · 12 citations
  3. 3The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  4. 4Multistep molecular trajectory during monocytic myeloid-derived suppressor cell induction by diffuse large B-cell lymphoma cells2025
  5. 5Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target2025 · 17 citations