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September 17, 2025Journal for ImmunoTherapy of CancerOpen Access

MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment

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Authors

IHInbar A HabazXOXuejin OuNWNicole I. Wang

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Overview

Investigation reveals MAIT cells associate with poor survival in bladder cancer, suggesting a role in Treg cell accumulation.

Key Points

  • Heavier presence of MAIT cells in bladder cancer tumors correlates with poorer overall survival.
  • Analysis of tumor samples showed higher burdens in MAIT-sufficient mice compared to MAIT-deficient models.
  • Flow cytometry identified phenotypes of MAIT cells, which produced increased inflammatory cytokines in tumors.
  • Elevated regulatory T cell frequencies in MAIT-sufficient tumors suggest potential for immunosuppression.

Cite This Study

Habaz et al. (2025) studied this question.

synapsesocial.com/papers/68d42f69713b0b5dfea70ea1https://doi.org/10.1136/jitc-2025-012496
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