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December 8, 2025BloodOpen Access

Multistep molecular trajectory during monocytic myeloid-derived suppressor cell induction by diffuse large B-cell lymphoma cells

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Authors

YSYuji ShimuraTNTakahisa NakamuraSMShinsuke Mizutani

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Overview

Observational analysis reveals myeloid-derived suppressor cells are induced by DLBCL cells, highlighting treatment resistance mechanisms in immune-cell therapies.

Key Points

  • Monocytic myeloid-derived suppressor cells were effectively induced from PBMCs by four human DLBCL-derived cell lines.
  • Gene expression profiles showed dynamic shifts in inflammatory response, particularly via tumor microenvironment factors.
  • Microarray analysis identified cytokine modulation including MIF and interleukin-10 as key drivers of M-MDSC induction.
  • Targeting phase-specific cytokines and molecules may enhance outcomes in chimeric antigen receptor T-cell therapy and bispecific antibodies.

Cite This Study

Shimura et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a0https://doi.org/10.1182/blood-2025-7091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Celmods potently inhibit m-MDSC induction by targeting IL-10 and MIF in multiple myeloma2025
  2. 2Cutaneous diffuse large B-cell lymphoma induce a macrophage immunosuppressive phenotype through IL-10 secretion2025
  3. 3AML blasts and monocytic myeloid-derived suppressor cells (M-MDSC) inhibit human mucosal-associated invariant t (MAIT) cells activation.2025
  4. 4MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response2025 · 6 citations
  5. 5IL-17–Induced CD70 expression promotes T-cell suppression in DLBCL: Implications for immune escape and T-cell exhaustion2025