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September 10, 2025Neuro-Oncology AdvancesOpen Access

Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-Neutrophil axis

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Authors

SKSeketoulie KeretsuTHTaijun HanaALAlexander Lee

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Overview

Analysis shows that MAIT cells contribute to immunosuppressive mechanisms in glioblastoma, suggesting a MAIT-neutrophil axis.

Key Points

  • MAIT cells in glioblastoma were found to play a significant immunosuppressive role, indicating a novel therapeutic target.
  • Flow cytometry revealed a notable reduction of MAIT cell frequency and Th1 cytokine production in GBM patients.
  • Significant gene signature correlations were observed, with MAIT cells linked to poor patient survival outcomes.
  • Spatial imaging confirmed the co-localization of MAIT cells and tumor-associated neutrophils within glioblastoma tissues.

Cite This Study

Keretsu et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64794f33https://doi.org/10.1093/noajnl/vdaf173
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Also Consider

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  2. 2AML blasts and monocytic myeloid-derived suppressor cells (M-MDSC) inhibit human mucosal-associated invariant t (MAIT) cells activation.2025
  3. 3Immune features of graft‐derived mucosal‐associated invariant T cells predict gastrointestinal graft‐versus‐host disease2026
  4. 4Unconventional T cells in anti-cancer immunity2025 · 1 citations
  5. 5Single‐Cell RNA Sequencing Reveals Dynamic Expression Patterns of MAIT Cells and Macrophage Subpopulations in Myocardial Injury Model2026