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December 8, 2025Blood

Peripheral immune checkpoints predict prognosis and reveal PD-1/treg/IL-10 crosstalk in B cell lymphoma

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Authors

SLSijia LiRZRuixin Zheng

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Overview

Observational analysis revealed immune checkpoint expression predicts prognosis in B-cell lymphoma, suggesting therapeutic targets.

Key Points

  • The expression of PD-1 on T cells significantly correlates with disease progression and treatment outcomes.
  • Patients with aggressive B-cell lymphoma exhibited higher levels of multiple immune checkpoints compared to indolent types.
  • Analysis of peripheral immune checkpoints identified prognostic markers that predict relapse or complete remission in patients.
  • These findings highlight the need for further studies on therapeutic targets to improve B-cell lymphoma management.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69chttps://doi.org/10.1182/blood-2025-7088
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Also Consider

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  1. 1Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms2025
  2. 2A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients2025
  3. 3Clinicopathological Significance of Tumor-Infiltrating T Lymphocytes and Macrophages in Primary Large B-Cell Lymphoma of Immune-Privileged Sites2025 · 1 citations
  4. 4Identification of the IFN-γ/IL-4 ratio as a prognostic biomarker and development of an immune-related prognostic model in diffuse large B-cell lymphoma2025 · 1 citations
  5. 5Prognostic analysis of immunomarkers for non-small cell lung cancer2025