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September 5, 2025Open Access

Prognostic analysis of immunomarkers for non-small cell lung cancer

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Authors

XWXinmei WangZYZhi-Qiong YuWHWeihua Hu

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Overview

Retrospective analysis shows PD-L1 correlates with tumor size in NSCLC, suggesting prognostic utility.

Key Points

  • Higher PD-L1 expression correlates with increased tumor size, and CD8 + TILs correlate with lymph node metastasis.
  • Survival analysis indicates longer PFS of 15 months in CD4 + TILs low infiltration patients compared to 6 months in high infiltration.
  • Multifactorial Cox regression highlights PD-L1 high expression and lung adenocarcinoma as independent risk factors for PFS.
  • Combined assessment of PD-L1 and immune infiltration traits may guide individualized immunotherapy strategies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f728https://doi.org/10.21203/rs.3.rs-7042926/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PD-L1 Expression as a Predictor of Time to Progression in Metastatic Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Retrospective Single-Center Study2026
  2. 2Evaluating the significance of combining PD-L1 and TILs as biomarkers in non-small cell lung cancer patients treated with immunotherapy: a systematic review2025
  3. 3PDL-1 in non-small cell lung cancer (NSCLC): Association with molecular alterations and clinical outcome2025
  4. 4PROGNOSTIC SIGNIFICANCE OF TP53 AND PD-L1 DEPENDING ON THE TYPE OF ADJUVANT THERAPY IN PATIENTS WITH NON-SMALL CELL LUNG CANCER2025
  5. 5Periphery TH/TS ratio and TP53 mutation predict the efficacy of ICI-based therapy in advanced non-small cell lung cancer with high PD-L1 expression2025