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September 5, 2025OncoImmunologyOpen Access

A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients

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Authors

JGJoao GorgulhoTTTimo TrenknerEKEva Kinkel

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Overview

Analysis of soluble and membrane-bound immune checkpoints reveals their potential as biomarkers for lymphoma outcomes.

Key Points

  • High levels of soluble immune checkpoints in lymphoma patients are linked to worse disease control and survival.
  • The combined score of three soluble immune checkpoints outperforms standard prognostic methods like NCCN-IPI.
  • Membrane-bound markers in peripheral blood mononuclear cells provide additional prognostic value.
  • Prospective validation of the 2COMPIC-Score could improve therapy decision-making in lymphoma patients.

Cite This Study

Gorgulho et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a06chttps://doi.org/10.1080/2162402x.2025.2543511
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