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September 5, 2025BMC CancerOpen Access

Identification of the IFN-γ/IL-4 ratio as a prognostic biomarker and development of an immune-related prognostic model in diffuse large B-cell lymphoma

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Authors

PZPan ZhouYZYuwei ZhouYLYang Liu

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Overview

Analysis identifies IFN-γ/IL-4 ratio and CD4 + T cell count as key prognostic indicators, suggesting better survival outcomes.

Key Points

  • A high IFN-γ/IL-4 ratio predicts better overall survival in DLBCL patients, highlighting its prognostic value.
  • Elevated CD4 + T cell counts correlated with improved progression-free survival, reinforcing immune system involvement.
  • An immune-related prognostic score model was developed, refining existing prognostic indices for better risk stratification.
  • Age and low CD8 + T cell counts were linked to worse outcomes, indicating complex interactions in DLBCL prognosis.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d6477762ahttps://doi.org/10.1186/s12885-025-14737-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms2025
  2. 2Elevated serum IL-10/IL-6 ratio as a novel biomarker for secondary central nervous system lymphoma and poor prognosis in DLBCL2025
  3. 3Establishment and Evaluation of Prognostic Prediction Model for Diffuse Large B-cell Lymphoma Patients Based on International Prognostic Index and FAT4, TP53 Mutation2025 · 1 citations
  4. 4Peripheral immune checkpoints predict prognosis and reveal PD-1/treg/IL-10 crosstalk in B cell lymphoma2025
  5. 5Construction of a prognostic model for new diffuse large B-cell lymphoma and research on risk factors for secondary central nervous system infiltration2025