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December 8, 2025Blood

Immune dysregulation in newly diagnosed DLBCL: From clinical observations to molecular mechanisms

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Authors

YPYuanyuan Pan

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Overview

Analysis shows immune profiling correlates with prognosis and infection risk in newly diagnosed DLBCL patients, indicating personalized management strategies.

Key Points

  • Infection risk was associated with distinct immune dysregulation, indicating compromised cellular immunity in DLBCL patients.
  • Low percentages of effector memory T cells correlated with worse treatment outcomes, highlighting critical prognostic factors.
  • Logistic regression analysis identified specific immune subsets as key indicators for infection risk and overall prognosis.
  • Findings establish a novel biomarker framework that may inform risk-adapted prophylaxis in DLBCL management.

Cite This Study

Yuanyuan Pan (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69bhttps://doi.org/10.1182/blood-2025-7085
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