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August 15, 2025eJHaemOpen Access

Trends, Predictors, and Outcomes of Critically Ill Patients With Sickle Cell Disease in the United States

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Authors

TNTochukwu NzeakoOAOlayemi AdeniranSKSaranjeet Kaur

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Overview

Analysis highlights increasing ICU admissions for sickle cell disease patients, suggesting a rise in morbidity.

Key Points

  • Prevalence of ICU admission for critically ill sickle cell disease patients increased by 126%.
  • Out of 5941 ICU admissions, 2826 patients (47.6%) experienced adverse clinical events.
  • Predictors of adverse clinical events include male sex, older age, and multiple comorbidities.
  • Patients with adverse clinical events were at higher risk for complications like cardiac arrest and sepsis.

Cite This Study

Nzeako et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771ecahttps://doi.org/10.1002/jha2.70111
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Also Consider

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  1. 1Racial and socioeconomic disparities in transfusion utilization among hospitalized sickle cell disease patients: An analysis of the 2022 national inpatient sample2025
  2. 2Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  3. 3Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis2025
  4. 4Clinical and Microbiological Profile of Infections in Hospitalized Patients with Sickle Cell Disease: A Tertiary Care Centre Experience from Central India2025
  5. 5Clinical Characteristics and Outcomes of Patients Admitted in Cardiac Intensive Care Unit with Cardiogenic Shock: A Single-Center Study2025