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December 8, 2025BloodOpen Access

Pulmonary hypertension as an independent predictor of mortality in hospitalized sickle cell disease patients: A national analysis of comorbidities and outcomes

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Authors

BCBrett CohenHBHarsh BhalalaNRNicholas Roma

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Overview

Analysis reveals pulmonary hypertension significantly predicts mortality in sickle cell disease patients, suggesting urgency for targeted treatments.

Key Points

  • Mortality risk increases significantly with pulmonary hypertension in sickle cell disease patients, independent of other factors.
  • Adjusted odds ratios highlight mortality ties to pulmonary hypertension (OR 1.71), while heart failure had no similar effect.
  • Analysis of over 287,000 hospitalizations for sickle cell disease showed increased length of stay and charges linked with complications.
  • Rising patient prevalence of comorbidities like diabetes and chronic kidney disease necessitates focused clinical management for better outcomes.

Cite This Study

Cohen et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9a0https://doi.org/10.1182/blood-2025-2960
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis2025
  2. 2Cardiopulmonary Hemodynamic Determinants of Long-Term Survival in Sickle Cell Disease: Insights from the ETENDARD Study.2025 · 10 citations
  3. 3Impact of pulmonary hypertension on in-hospital outcomes among patients hospitalized with multiple myeloma: A 2015–2022 national inpatient sample analysis2025
  4. 4Pulmonary Hypertension in Sickle Cell Disease: A Case Series2025
  5. 5Pulmonary Hypertension Associated with Systemic Sclerosis (Review)2025