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December 8, 2025Blood

Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)

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Authors

AIAjay Iyer

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Overview

Retrospective analysis reveals higher mortality odds for venous thromboembolism in sickle cell disease adults, highlighting critical care needs.

Key Points

  • Sickle cell disease patients had nearly double the odds of venous thromboembolism-related hospitalizations compared to non-SCD patients.
  • Among 1.42 million hospitalizations, only 0.5% were SCD-related VTE admissions, with notable demographic differences.
  • This observational study analyzed multiple years of data, utilizing the National Inpatient Sample for comprehensive insights.
  • Results indicate a consistent need for enhanced preventive strategies for venous thromboembolism in this high-risk population.

Cite This Study

Ajay Iyer (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e13ahttps://doi.org/10.1182/blood-2025-4751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study2025
  2. 2Interplay Between Sickle Cell Disease and Thrombosis: A Single Center Experience of Pathophysiology and Potential Risk Factors2025 · 1 citations
  3. 3Treatment patterns, acute-care utilization, and clinical outcomes among patients with lung cancer and sickle cell disease: A multicenter propensity score–matched real-world analysis.2026
  4. 4Venous thromboembolism and bleeding rates in pregnant and postpartum patients with sickle cell disease2025
  5. 5Outcomes of long-term anticoagulation use in patients hospitalized with sickle cell vaso-occlusive crisis: A weighted analysis of the national inpatient sample (2016–2022)2025