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December 8, 2025Blood

Disrupting CXCL12-DPP4-GPC3 axis redistributes leukemia stem cells and confines AML cells within bone marrow niche

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Authors

WZWenxuan ZhouLLLinheng Li

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Overview

Experimental analysis shows LSC redistribution and functional exhaustion in bone marrow, highlighting the need for therapeutic DPP4 targeting.

Key Points

  • Leukemia stem cells exhibited a shift to the central marrow while losing self-renewal capabilities, and proliferated more quickly.
  • Single-cell RNA sequencing unveiled a relationship between N-cadherin+ mesenchymal stromal cells and Cxcl12 levels.
  • Immunofluorescence microscopy demonstrated altered localization patterns in response to Dpp4 deletion and axial disruption.
  • This research suggests that targeting the CXCL12-DPP4-GPC3 axis could provide a novel therapeutic strategy for acute myeloid leukemia.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d41bhttps://doi.org/10.1182/blood-2025-658
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