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December 5, 2025Nature CommunicationsOpen Access

Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy

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Authors

MZMingming ZhuHYHaoxiang YangKQKai-long Qiu

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Overview

Inhibiting ALDH1A1 reduces stemness in leukemic stem cells, suggesting enhanced NK cell therapy in acute myeloid leukemia.

Key Points

  • NK cell-mediated immunotherapy enhances cytotoxicity against acute myeloid leukemia cells.
  • Inhibiting ALDH1A1 improves cellular stiffness by promoting F-actin polymerization in stem cells.
  • Microfluidic chips facilitate the isolation of leukemic stem cells based on their mechanical properties.
  • Targeting the mechanical aspects of leukemic stem cells may improve clinical outcomes in AML treatment.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/693231118e51979591dce0echttps://doi.org/10.1038/s41467-025-65842-5
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