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October 2, 2025Open Access

High-Dimensional Spatiotemporal Single-Cell and 3D Atlas of the Bone Marrow Microenvironment during Leukemic Progression

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Authors

LLLan‐Zhu LiIRIsabelle RottmannGIGeoffrey T. Ivison

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Overview

Advanced chronic myeloid leukemia shows altered bone marrow microenvironment and immune evasion features, indicating significant pathology and cellular reprogramming.

Key Points

  • Leukemic progression results in cell type alterations, with a significant loss of B cells and plasma cells, highlighting the impact on immune response.
  • Advanced chronic myeloid leukemia revealed a marked expansion of immature vasculature and immune cell exhaustion, significantly altering the bone marrow microenvironment.
  • Using 3D microscopy and immune profiling, analysis tracked over 2 million cells to uncover specific cellular neighborhoods associated with leukemic transformation.
  • Laser-capture microdissection showed distinct genetic expression changes in megakaryocytes between newly diagnosed and advanced chronic myeloid leukemia cases.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68de6f4283cbc991d0a22dcfhttps://doi.org/10.1101/2025.09.27.678113
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