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December 8, 2025BloodOpen Access

Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients

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Authors

YPYebo PengYHYingying HuoWGWen Gao

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Overview

Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients, indicating immunosenescence affects treatment responses.

Key Points

  • This research aims to explore immune cell senescence in elderly acute myeloid leukemia (AML) patients and identify potential targets for immunotherapy.
  • Analyzed scRNA-seq data from 63 bone marrow samples categorized into young and elderly AML patients and healthy controls.
  • Constructed a single-cell reference map of healthy controls and identified leukemic cells using a random forest model and reference-based methods.
  • Compared various immune cell types, transcription factor activities, and their features between elderly AML patients and controls.
  • Significantly lower proportions of immune cells in AMLs compared to healthy controls, indicating restricted immune cell abundance.
  • Increased proportions of CD8+ T cells and neutrophils were observed with age in AMLs, while neutrophils decreased in HCs.
  • FOXO1 activity was lower in elderly AML patients, suggesting less capability to control T cell differentiation, while JUNB activity differed between patient groups.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d22ehttps://doi.org/10.1182/blood-2025-1409
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Also Consider

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  1. 1Integrative clinical and molecular analysis of outcome in elderly African ancestry Acute Myeloid Leukemia2025
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  4. 4Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  5. 5The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025