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December 8, 2025Cephalalgia

miR-382-5p and miR-34a in migraine: Expression in monocytes and a post-hoc exploratory comparison with expression in peripheral blood mononuclear cells

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Authors

RGRosaria GrecoFBFederico BighianiAZAnnamaria Zanaboni

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Overview

Cross-sectional study shows altered monocyte miRNA levels in chronic migraine, indicating their role in migraine pathophysiology.

Key Points

  • To determine the expression levels of miR-34a and miR-382-5p in monocytes of migraine patients compared to healthy controls.
  • Cross-sectional, controlled study design
  • Inclusion of participants with episodic migraine, chronic migraine with medication overuse, and healthy controls
  • Assessment of miRNA expression using qRT-PCR, normalizing against U6 RNA
  • Logistic regression analysis to confirm expression differences
  • Higher miR-382-5p expression in monocytes from episodic migraine and chronic migraine group compared to healthy controls
  • Higher miR-34a expression in monocytes from episodic migraine and chronic migraine group compared to healthy controls
  • Significant differences in monocyte miRNA expression between chronic and episodic migraine after adjustments for confounders

Cite This Study

Greco et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236ca68https://doi.org/10.1177/03331024251386769
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR-197, miR-101, and miR-143 and Pro-Inflammatory Cytokines in Migraine2025
  2. 2Cellular and molecular characterisation of the peripheral immune environment in migraine2025
  3. 3Migraine and neuroinflammation: correlation of adipokines and cytokines with clinical features2025
  4. 4Serum Levels of miR-34a-5p, miR-30b-5p, and miR-140-5p Are Associated with Disease Activity and Brain Atrophy in Early Multiple Sclerosis2025
  5. 5Plasma adrenomedullin levels in migraine: A registry for migraine (REFORM) study2025