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August 20, 2025PAIN ReportsOpen Access

Cellular and molecular characterisation of the peripheral immune environment in migraine

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Authors

JOJ A O'BrienBHBenjamin HengSASeong Beom Ahn

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Overview

This research shows distinct immune changes across migraine phases in patients, indicating potential biomarkers.

Key Points

  • Distinct proinflammatory signatures were observed across different phases of migraine, highlighting immune involvement.
  • Increased plasma proteins associated with cell adhesion and enzymatic activity were found in migraine patients.
  • Cross-sectional assessment used high-dimensional approaches like proteomics and single-cell mass cytometry.
  • These findings may assist in identifying immune factors contributing to migraine attacks, supporting future therapeutic strategies.

Cite This Study

O'Brien et al. (2025) studied this question.

synapsesocial.com/papers/68af735d7567bf4f94fecd60https://doi.org/10.1097/pr9.0000000000001317
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