September 10, 2025International Journal of Molecular SciencesOpen Access

Serum Levels of miR-34a-5p, miR-30b-5p, and miR-140-5p Are Associated with Disease Activity and Brain Atrophy in Early Multiple Sclerosis

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Authors

RORiccardo OrlandiUniversity of Verona LTLeopoldo TorresanUniversity of Verona FGFrancesca GobbinUniversity of Verona

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Implication

Prospective analysis identifies miR-34a-5p, miR-30b-5p, and miR-140-5p associated with disease activity, suggesting their role as biomarkers in multiple sclerosis.

Key Points

Serum levels of miR-34a-5p, miR-30b-5p, and miR-140-5p correlate with disease activity in multiple sclerosis patients.
Significant differences were noted, with miR-34a-5p higher in patients with gadolinium-enhancing lesions (p < 0.001).
Real-time PCR assays were used to analyze serum miRs across a cohort of 51 recently diagnosed MS patients.
These findings highlight the potential of serum microRNAs as disease activity markers in early multiple sclerosis.

Cite This Study

Orlandi et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d647867a0 https://doi.org/10.3390/ijms26178597

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Implication

Prospective analysis identifies miR-34a-5p, miR-30b-5p, and miR-140-5p associated with disease activity, suggesting their role as biomarkers in multiple sclerosis.

Serum Levels of miR-34a-5p, miR-30b-5p, and miR-140-5p Are Associated with Disease Activity and Brain Atrophy in Early Multiple Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Serum Levels of miR-34a-5p, miR-30b-5p, and miR-140-5p Are Associated with Disease Activity and Brain Atrophy in Early Multiple Sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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