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December 8, 2025Journal of Cellular and Molecular MedicineOpen Access

Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic‐Specific Lung Cancer

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Authors

JLJingyang LiuLWLijuan WuXWXiao Wang

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Overview

Cohort study reveals protein biomarkers in lung cancer, suggesting targeted therapies may improve outcomes.

Key Points

  • This research identifies protein biomarkers and therapeutic targets specific to lung cancer subtypes.
  • Cohort study based on the UK Biobank population with 47,000 participants.
  • Blood samples measured for 2,923 unique proteins.
  • Logistic regression, Mendelian randomisation, and transcriptomic validation were used for analysis.
  • Tier 1 proteins included GP1BA and ACADSB linked to specific cancer types.
  • Druggability evaluation indicates potential for repurposing existing drugs for lung cancer treatment.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c1abhttps://doi.org/10.1111/jcmm.70866
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  1. 1Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives2025
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  4. 4Plasma Proteome-Genome Integration Reveals Novel Protein Biomarkers and Drug Targets Linked to Breast Cancer Survival2025
  5. 5Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma2025