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August 17, 2025Scientific ReportsOpen Access

Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma

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Authors

SCShizhao ChengHZHao ZhangZSZhenliang Shi

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Overview

Mendelian randomization reveals gene associations with lung squamous cell carcinoma risk, implying potential treatment targets.

Key Points

  • Mendelian randomization identified several genes associated with lung squamous cell carcinoma risk and prognosis.
  • Key findings include protective factors like DNMT1 and CPA4, possibly aiding in cancer management.
  • Using datasets from ieu_b_4953 and finngen, methods included Bayesian co-localization and summary-data-based MR analysis.
  • Understanding gene roles in immune infiltration helps delineate lung squamous cell carcinoma pathogenesis further.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68af33e3cf1dd9ea359e8ef1https://doi.org/10.1038/s41598-025-15977-8
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