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September 10, 2025Archives of Medical ScienceOpen Access

Plasma Proteome-Genome Integration Reveals Novel Protein Biomarkers and Drug Targets Linked to Breast Cancer Survival

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Authors

ZCZ. Alexander CaoQPQiyun PengSTShenglan Tan

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Overview

Mendelian randomization reveals key protein associations with breast cancer survival, highlighting potential biomarkers and drug targets.

Key Points

  • The study identified 27 proteins significantly associated with breast cancer survival, providing promising therapeutic targets.
  • Among the identified proteins, SH3BGRL3 and GRHPR have strong evidence linking them to breast cancer prognosis.
  • Utilizing proteome-wide Mendelian randomization allowed for a novel integration of genetic and proteomic data in breast cancer research.
  • This research highlights the potential for existing drugs to target identified proteins, suggesting new avenues for breast cancer treatment.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479cef8https://doi.org/10.5114/aoms/208246
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