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August 25, 2025PLoS GeneticsOpen Access

Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives

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Authors

ZLZhangyan LyuGSGuojin SiMXMingzhao Xing

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Overview

Mendelian randomization identifies proteins associated with lung cancer subtypes in UK Biobank, suggesting new biomarkers.

Key Points

  • Twenty-five proteins were significantly linked to lung cancer, with 15 novel findings, providing potential new biomarkers for diagnosis or treatment.
  • The strongest associations were observed for RPL14 and AGER, indicating they could serve as therapeutic targets in lung cancer management.
  • Pathway analysis showed the identified proteins are involved in immune regulation and tumorigenesis processes, impacting lung cancer development.
  • Druggable targets were identified, highlighting the potential therapeutic applications of RPL14 and AGER in lung cancer treatment.

Cite This Study

Lyu et al. (2025) studied this question.

synapsesocial.com/papers/68af7b2a7567bf4f94ff31f0https://doi.org/10.1371/journal.pgen.1011821
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