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September 10, 2025Carcinogenesis

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium

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Authors

MDMei DongATAbhinav ThakralKSKarl Smith-Byrne

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Overview

Pooled analysis reveals genetic variants affecting prognosis in early-stage non-small cell lung cancer (NSCLC), suggesting key pathways for future research.

Key Points

  • The study identified significant genetic variants that affect prognosis in early-stage NSCLC, indicating potential new pathways.
  • Two crucial variants were discovered: a significant locus at 9q21.31 (rs117979484) and a significant variant in the squamous cell carcinoma subgroup (rs138467404).
  • Phase 1 employed a multivariable Cox PH model on 3428 NSCLC patients to discover prognostic genetic variants and validate significant findings.
  • These findings highlight the potential for novel interventions in early-stage NSCLC prognosis and warrant further exploration of suggested variants.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d64796996https://doi.org/10.1093/carcin/bgaf031
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