Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Inhibition of the aryl hydrocarbon receptor eliminates leukemia stem cells in murine models of Acute Myeloid Leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

RDRhea DesaiPBPeter BrowettPKPurvi M. Kakadia

Discussion

Loading...

Member takes

Overview

Observational analysis shows reduced leukemia stem cells in murine AML models with AHR antagonist treatment, suggesting new strategies for AML therapy.

Key Points

  • AHR antagonist treatment eliminated leukemia stem cells in murine models, preventing leukemia progression.
  • AHR inhibition led to unmeasurable leukemia stem cell frequency, reducing it significantly from about 1:4 to 1:44.
  • Analysis of bone marrow transplantation revealed differential effects of AHR modulation on leukemia stem cells versus healthy hematopoietic stem cells.
  • AHR modulation presents a promising therapeutic target for developing effective AML treatments with fewer side effects.

Cite This Study

Desai et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e149https://doi.org/10.1182/blood-2025-6101
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy2025 · 2 citations
  2. 2CⅡTA-mediated up-regulation of MHC reverses immune evasion of leukemia stem cells in refractory/relapsed AML2025
  3. 3Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models2025 · 3 citations
  4. 4Disrupting CXCL12-DPP4-GPC3 axis redistributes leukemia stem cells and confines AML cells within bone marrow niche2025 · 1 citations
  5. 5Disrupting monocytic AML and monocytic leukemia stem cells with a novel cladribine regimen: From bench to bedside2025