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July 15, 2025Open Access

Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells

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Authors

SGShira Glushakow-SmithIKImit KaurSSSimone Sidoli

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Overview

Targeting PI3 kinase reveals vulnerabilities in leukemic stem cells, suggesting new strategies against AML resistance mechanisms.

Key Points

  • Main finding shows that leukemic stem cells rely on the P110 alpha isoform of PI3K for survival.
  • PI3K inhibition results in decreased EZH2 protein levels, leading to a resistance mechanism in AML cells.
  • Combining a PI3K inhibitor with an EZH1/2 dual inhibitor effectively targets leukemic stem cells and overcomes resistance.
  • This approach provides a potential new therapeutic regimen for improving treatment outcomes in patients with AML.

Cite This Study

Glushakow-Smith et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc753https://doi.org/10.1101/2025.07.11.663968
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