Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 4, 2025The Journal of Toxicological SciencesOpen Access

Renal effects of excessive fructose intake in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats

View Full Paper
Ask AI
Bookmark
Share

Authors

KTKaoru ToyodaTTTadakazu TakahashiTSToshiyuki Shoda

Discussion

Loading...

Member takes

Overview

High-fructose intake worsens nephropathy and urinary changes in diabetic SDT fatty rats, suggesting risk of kidney injury.

Key Points

  • High-fructose diet leads to increased urinary stone formation and worsens nephropathy in diabetic rats.
  • In female SDT fatty rats, fructose intake elevated calcium and phosphate excretion significantly.
  • Histopathological analysis revealed mineral deposition and inflammatory changes in the kidneys post-fructose diet.
  • Findings underscore the SDT fatty rat model's importance for exploring diabetes complications and dietary impacts.

Cite This Study

Toyoda et al. (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca2025https://doi.org/10.2131/jts.50.727
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Consumption of High-Fat-High-Fructose Diet Decreased Insulin Sensitivity and Damaged the Islets of Langerhans on Sprague Dawley Rats2025
  2. 2Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats2025
  3. 3Metabolic profile alterations in juvenile rats with bladder overactivity induced by short-term high-fructose intake2025
  4. 4Impact of Fructose‐Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats2025
  5. 5Effects of Hypertension Induced by 0.3% Saline Loading on Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats2025