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September 18, 2025Amerta NutritionOpen Access

Long-Term Consumption of High-Fat-High-Fructose Diet Decreased Insulin Sensitivity and Damaged the Islets of Langerhans on Sprague Dawley Rats

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Authors

AKAdelya Desi KurniawatiLKLuh Shanti KuswandariAHAlfiani Hidayanti

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Overview

Analysis shows that long-term HFHF diet reduces insulin sensitivity and damages pancreas in Sprague Dawley rats, indicating risks for type 2 diabetes.

Key Points

  • The HFHF diet significantly decreased insulin sensitivity and led to pancreatic damage in rats.
  • Insulin sensitivity, measured by HOMA-IR, showed significant reduction with p-value<0.05 after 17 weeks.
  • The study involved 36 male Sprague Dawley rats, with diet monitored over a period to assess effects.
  • Findings highlight that long-term HFHF consumption could increase diabetes risk due to pancreatic islet damage.

Cite This Study

Kurniawati et al. (2025) studied this question.

synapsesocial.com/papers/68d434d6713b0b5dfea73d2ehttps://doi.org/10.20473/amnt.v9i3.2025.469-478
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal effects of excessive fructose intake in Spontaneously Diabetic Torii-&lt;i&gt;Lepr&lt;/i&gt;fa (SDT fatty) rats2025
  2. 2Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats2026
  3. 3Temporal changes in blood glucose levels and organ histopathology in alloxan-induced diabetic rats2025
  4. 4Effect of Moderate-Intensity Continuous Training (MICT) on Pancreatic Islet of Langerhans’ Morphology and Cell Count of Female Rats (Rattus norvegicus) Exposed to High-Calorie Diet2025
  5. 5Evaluation of the Nutritional Profile and Obesogenic Potential of a Formulated High-Fat Diet2025