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October 15, 2025PeerJOpen Access

Metabolic profile alterations in juvenile rats with bladder overactivity induced by short-term high-fructose intake

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Authors

XCXu CuiZCZhiqiang ChenLXLong-Yao Xu

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Overview

Research reveals high-fructose diet causes metabolic alterations and OAB-like symptoms in juvenile rats, suggesting potential therapy avenues.

Key Points

  • High-fructose intake induces significant metabolic and functional changes in juvenile rats, increasing urination frequency and impairing bladder function.
  • The model group exhibited disrupted body weight and lipid metabolism, with heightened oxidative stress and altered energy metabolism patterns.
  • Assessment included Western blot analysis and metabolomic profiling to confirm activation of the CaMKK2/AMPK signaling pathway in bladder tissue.
  • Findings highlight the link between fructose metabolism and bladder dysfunction, indicating the need for further exploration of antioxidant strategies.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/68efbd16d61273c8652d8216https://doi.org/10.7717/peerj.20186
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal effects of excessive fructose intake in Spontaneously Diabetic Torii-<i>Lepr</i>fa (SDT fatty) rats2025
  2. 2Impact of Fructose‐Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats2025
  3. 3Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats2025
  4. 4Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats2026
  5. 5High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction2025