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November 30, 2025European journal of medical researchOpen Access

Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study

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Overview

Mendelian randomization analysis reveals testosterone's protective role against adiposity in males while highlighting obesity risks in females.

Key Points

  • Testosterone levels show a negative correlation with obesity in males, and estradiol displays a complex relationship with adiposity.
  • Boys had lower obesity risk with genetically increased testosterone, while females showed a positive link between FAI and visceral fat.
  • Analysis employed multivariate linear regression and generalized additive models to assess associations between sex hormones and obesity-related parameters.
  • Findings may inform gender-specific interventions for obesity-related health issues, highlighting distinct hormonal influences.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/692b9d931d383f2b2a379bf4https://doi.org/10.1186/s40001-025-03470-x
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