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October 2, 2025Cancer Prevention Research

Effect modification by levels of sex hormones in the association between adiposity and cancer incidence in the UK Biobank

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Authors

LLLeeAnn LucasYLYujia LuEGE. Giovannucci

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Overview

Cohort analysis demonstrates significant cancer risk variance based on adiposity and sex hormones in males and females.

Key Points

  • Hazard ratios indicate that BMI is linked to a higher cancer risk, particularly in males with high SHBG levels.
  • Among 451,500 UK Biobank participants, 42,949 cancers were documented over a median follow-up of 13.1 years.
  • Cox regression models highlighted differing impacts of adiposity on esophageal, liver, and colorectal cancers based on sex hormone levels.
  • The findings suggest that sex hormone binding globulin may significantly influence adiposity-related cancer risks.

Cite This Study

Lucas et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2187ahttps://doi.org/10.1158/1940-6207.capr-25-0246
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