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October 2, 2025Obesity Reviews

Sex Disparities in Obesity: A Comprehensive Review of Hormonal and Genetic Influences on Obesity‐Related Phenotypes

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Authors

YLYu‐Gyeong LeeYKYoo‐Ree KangYCYoomee Chang

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Overview

This review examines hormonal and genetic influences on obesity-related traits, revealing sex-specific factors in adipose tissue distribution.

Key Points

  • Obesity's rapid increase is linked to various chronic diseases, and understanding sex disparities is crucial.
  • Large-scale genome-wide association studies identified genetic factors that contribute to sex-specific obesity traits.
  • Men typically have more visceral adipose tissue while women possess more subcutaneous adipose tissue, influenced by hormones.
  • This review highlights the role of estrogen and explores genetic factors linked to obesity, emphasizing sex differences.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68de79715b556a9128e1b06fhttps://doi.org/10.1111/obr.70026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice2025
  2. 2Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology2025 · 4 citations
  3. 3Sex‐Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for <scp>BMI</scp>2025
  4. 4Associations between sex hormones and obesity-related indicators: results from the NHANES and Mendelian randomization study2025
  5. 5Heterogeneity of Obesity and Its Predictive Factors: A Narrative Review of Recent Human and Rodent Studies2025