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October 23, 2025American Journal of Hypertension

Bidirectional Mendelian Randomization Analysis Reveals Protective Effects of Bioavailable Testosterone Against Hypertensive Disorders of Pregnancy

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Authors

HZHua ZhangCQChen QingPDPingyun Ding

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Overview

Bidirectional Mendelian randomization shows bioavailable testosterone as a protective factor against hypertensive disorders, suggesting key metabolic and inflammatory pathways.

Key Points

  • Bioavailable testosterone is a protective factor against hypertensive disorders of pregnancy, with a reported OR of 0.81 and P=0.023.
  • Mendelian randomization analysis links testosterone levels and hypertensive disorders, alongside sensitivity analyses confirming robust results.
  • Potential mechanisms include metabolic pathways and expression quantitative trait loci interaction affecting inflammation modulation.
  • Findings suggest bioavailable testosterone may support cardiovascular function through its protective role in hypertensive disorders.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3c7chttps://doi.org/10.1093/ajh/hpaf208
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