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November 30, 2025Frontiers in ImmunologyOpen Access

Metabolic reprogramming of macrophages in chronic obstructive pulmonary disease

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Authors

ZQZiwen QinWLWenjuan LiuCHChuan-jun Huang

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Overview

Review reveals altered macrophage metabolism in COPD, suggesting immunometabolic pathways may guide treatment.

Key Points

  • Chronic obstructive pulmonary disease (COPD) shows altered immune cell metabolism, particularly in macrophages.
  • Evidence highlights oxidative stress and immune cells' metabolic pathways as crucial mechanisms in COPD.
  • Review of macrophage polarization phenotype and metabolic characteristics in the context of COPD treatment.
  • Understanding these pathways may support novel approaches for targeting immunometabolism in COPD management.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/692b9d7b1d383f2b2a3795dehttps://doi.org/10.3389/fimmu.2025.1684075
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  5. 5Macrophage metabolism in inflammatory heart disease: new insights and therapeutic implications2025 · 7 citations