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August 2, 2025Frontiers in ImmunologyOpen Access

Macrophages in chronic infections: regulation and remodeling

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Authors

HCHongle CuiMWMin WangSJShunchang Jiao

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Overview

Review discusses how macrophages modulate their functions via metabolic pathways in chronic infections, highlighting immune evasion implications.

Key Points

  • Macrophages play a crucial role in responding to infections by adapting their metabolic pathways.
  • Pathogens can exploit macrophage plasticity to evade the immune response, leading to chronic infections.
  • The review highlights the relationship between macrophage polarization and their metabolic reprogramming.
  • Understanding macrophage metabolism may reveal new avenues for enhancing trained immunity during chronic infections.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0475https://doi.org/10.3389/fimmu.2025.1594988
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Also Consider

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  1. 1Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics2025
  2. 2Macrophage metabolism in inflammatory heart disease: new insights and therapeutic implications2025 · 7 citations
  3. 3Metabolic reprogramming of macrophages in chronic obstructive pulmonary disease2025
  4. 4Ontogeny specification and epigenetic regulation of macrophage plasticity2025
  5. 5Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections2025