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October 9, 2025Frontiers in MedicineOpen Access

Macrophage metabolism in inflammatory heart disease: new insights and therapeutic implications

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Authors

AXAndy Peng XiangACAie ChangJZJi‐Chang Zhou

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Overview

Review reveals metabolic pathways shape macrophage function in inflammatory heart disease, suggesting new therapeutic roles.

Key Points

  • Metabolic pathways critically influence macrophage polarization and function in inflammatory heart disease.
  • Emerging insights into macrophage phenotypic diversity highlight their roles in tissue regeneration and injury responses.
  • Therapeutic targeting of macrophage metabolism may enhance repair processes and improve outcomes in cardiovascular diseases.
  • Comprehensive overview covers macrophage ontogeny, metabolic reprogramming, and implications for therapy in heart disease.

Cite This Study

Xiang et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e0ddhttps://doi.org/10.3389/fmed.2025.1664538
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