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October 15, 2025Frontiers in GeneticsOpen Access

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

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Authors

HGHui GuoWSWeilin SunFZFang‐Jie Zhao

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Overview

Observational analysis discovered novel macrophage biomarkers in chronic obstructive pulmonary disease, suggesting roles in immune dysregulation.

Key Points

  • Three key biomarkers were identified, potentially enabling targeted therapies for chronic obstructive pulmonary disease.
  • The nomogram model accurately predicted patient mortality, indicating the clinical relevance of the biomarkers.
  • Weighted gene co-expression network analysis revealed associations with metabolic pathways and B-cell receptor signaling.
  • In vitro experiments validated the findings, suggesting strong clinical implications for therapeutic strategies.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68efd921056559ef4287754fhttps://doi.org/10.3389/fgene.2025.1653163
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Also Consider

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  1. 1Bioinformatics identification of mitochondria and macrophage polarization-related genes in COPD and their potential mechanisms2025 · 1 citations
  2. 2Identification of Novel Lactylation-Related Biomarkers for COPD Diagnosis Through Machine Learning and Experimental Validation2025
  3. 3Omics-Assisted Biomarkers Identification and Docking-Based Therapeutic Exploration of Moringa Phytoconstituents in Chronic Obstructive Pulmonary Disease2025
  4. 4To reveal biomarkers related to macrophage and lactic acid metabolism in renal fibrosis and explore their mechanisms2025
  5. 5Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease2025